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Medication

Why After Some Time ADHD Medication Stops Working?

Mar 17, 2025 · 5 min

When I first started taking Elvanse (lisdexamfetamine) to manage my ADHD, my primary concern was simple: Would it help me focus? I wanted to stay on task, improve my concentration, and regain control over my impulsivity. Like many others starting stimulant medication, I understood that Elvanse worked by increasing dopamine and norepinephrine, two neurotransmitters critical for attention and motivation.

What I didn’t fully realize, however, was just how complex its effects would be on my brain’s neurochemistry. Over time, I noticed shifts—not just in focus, but in my overall mood, energy levels, and even how I responded to stress. Through discussions with my friend and researcher, Kristina Smith, I began to understand the deeper mechanisms at play.